CD26 (DPP4) Mouse Monoclonal Antibody [Clone ID: BA5b]

CAT#: AM12067FC-N

CD26 (DPP4) mouse monoclonal antibody, clone BA5b, FITC

Specifications

Product Data

• Clone Name: BA5b
• Applications: FC
• Recommended Dilution: Flow cytometry analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension.
  The content of a vial (2 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: A human T cell clone
• Specificity: The antibody recognizes CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
  Label: FITC
  State: Liquid Ig fraction
  Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use
• Conjugation: FITC
• Gene Name: Homo sapiens dipeptidyl-peptidase 4 (DPP4)
• Database Link:
  Entrez Gene 1803 Human
• Background: CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
• Synonyms: ADCP2, Dipeptidyl peptidase 4, DPP IV, Dipeptidyl peptidase IV, ADABP, TP103

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane