G protein alpha inhibitor 1 (GNAI1) Mouse Monoclonal Antibody [Clone ID: R4.5]

CAT#: AM12136PU-N

G protein alpha inhibitor 1 (GNAI1) mouse monoclonal antibody, clone R4.5, Purified

Product Images

Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: R4.5
• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/50.
  Western Blot.
• Reactivities: Bovine, Guinea Pig, Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Partially purified Gai1 protein from Rat brain (39-42kD).
• Specificity: Recognizes Gai1.
  Does not cross-react with Transducin, Gao, Gai2, Gai3, or Gas. ADP-ribosylation of ai1 proteins does not alter the reactivity.
  Cellular Localization: Cell membrane.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified IgG fraction
  Stabilizer: 0.2% BSA
  Preservative: 0.09% Sodium Azide
• Concentration: 0.2 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (GNAI1), transcript variant 1
• Database Link:
  Entrez Gene 14677 MouseEntrez Gene 25686 RatEntrez Gene 2770 Human
• Background: GTP binding proteins (G proteins) play a critical role in signal transduction by coupling receptors to effectors. The intracellular consequences of G protein activation include second messenger generation, protein phosphorylation, ion channel activation, gene induction, cell growth, and differentiation. Gi belongs to the pertussis toxin sensitive G proteins. Gi consists of three different subtypes of alpha subunits (alpha i1, alpha i2 and alpha i3).
• Synonyms: GNAI1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance, Chemokine signaling pathway, Gap junction, Leukocyte transendothelial migration, Long-term depression, Melanogenesis, Progesterone-mediated oocyte maturation, Tight junction