CD44 Mouse Monoclonal Antibody [Clone ID: 156-3C11]

CAT#: AM20041PU-S

CD44 mouse monoclonal antibody, clone 156-3C11, Purified

Specifications

Product Data

• Clone Name: 156-3C11
• Applications: IHC
• Recommended Dilution: Immunohistochemistry and Paraffin Sections: Use at 1/25-1/75 in ABC method.
  Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
  Positive Control: Human tonsil.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: BALB/C mice were injected with stimulated Human leukocytes.
• Specificity: This antibody is specific to a cell surface glycoprotein of 80-95kD, known as CD44, which is expressed on the surface of lymphocytes, monocytes, and granulocytes.
  This antibody reacts with red cells pretreated with 2-aminoethyl-isothiouronium bromide (AET).
  Cellular Localization: Cell membrane.
• Formulation: State: Purified
  State: Liquid purified IgG containing Sodium Azide as a preservative.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens CD44 molecule (Indian blood group) (CD44), transcript variant 1
• Database Link:
  Entrez Gene 960 Human
• Background: CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
• Synonyms: LHR, MDU2, MDU3, MIC4, CDw44, Epican, ECMR-III, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, PGP-1

Reference Data

• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
• Protein Pathways: ECM-receptor interaction, Hematopoietic cell lineage