Factor H (CFH) Mouse Monoclonal Antibody [Clone ID: OX-24]

CAT#: AM20110PU-N

Factor H (CFH) mouse monoclonal antibody, clone OX-24, Purified

Product Images

Immunohistochemistry: Factor H antibody staining of Formalin-Fixed, Paraffin-Embedded Human Liver followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Clone Name: OX-24
• Applications: ELISA, FC, IHC, IP, WB
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Immunohistochemistry on Paraffin Sections: 20 µg/ml.
  Immunoprecipitation.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified Human complement factor H protein
• Specificity: Clone OX-24 inhibits the binding of factor H to surface bound C3.
  This antibody recognizes the Human serum complement protein factor H and a 43-49kD truncated form of factor H.
• Formulation: PBS containing 0.02% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein G Chromatography.
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement factor H (CFH), transcript variant 1
• Database Link:
  Entrez Gene 3075 Human
• Background: Factor H (CFH) is a protein with twenty short consensus repeat (SCR) domains. Factor H is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in Factor H have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Synonyms: CFH, HF, HF1, HF2, H factor 1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades