Bone Sialoprotein (IBSP) (CD-BSP 108-122) Mouse Monoclonal Antibody [Clone ID: 243 8B1]

CAT#: AM20239PU-S

Bone Sialoprotein (IBSP) (CD-BSP 108-122) mouse monoclonal antibody, clone 243 8B1, Purified

Specifications

Product Data

• Clone Name: 243 8B1
• Applications: ELISA
• Recommended Dilution: ELISA: 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human CD-BSP
• Specificity: Recognizes Carbohydrate-deficient Bone Sialoprotein (CD-BSB/Tumor-BSP).
• Formulation: PBS, pH 7.4
  State: Purified
  State: Lyophilized purifed IgG fraction
• Reconstitution Method: Restore in aqua bidest to 1 mg/ml
• Purification: Protein G Chromatography
• Gene Name: Homo sapiens integrin binding sialoprotein (IBSP)
• Database Link:
  Entrez Gene 3381 Human
• Background: The protein encoded by the Bone Sialoprotein gene is a major structural protein of the bone matrix. It is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts, and it constitutes approximately 12% of the noncollagenous proteins in human bone. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
• Synonyms: Bone sialoprotein II, BSP II, IBSP, BNSP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: ECM-receptor interaction, Focal adhesion