Bone Sialoprotein (IBSP) (CD-BSP 108-122) Rat Monoclonal Antibody [Clone ID: IDBSP5]

CAT#: AM20240PU-S

Bone Sialoprotein (IBSP) (CD-BSP 108-122) rat monoclonal antibody, clone IDBSP5, Purified

Product Images

ELISA Standard curve showing measurement of Human BSP in a Sandwich immunoassay using AM20240PU as a Capture antibody and AM02057PU as a Detection antibody. OD was determined at 450 nm. The shown standard curve is for demonstration purposes only and can be influenced by Buffer, incubation conditions or dilution of the conjugate.

Specifications

Product Data

• Clone Name: IDBSP5
• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1/2000.
  Western Blot.
• Reactivities: Human
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human CD-BSP (108-122)
• Specificity: Recognizes Carbohydrate-deficient Bone Sialoprotein (CD-BSB/Tumor-BSP).
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purifed IgG fraction
• Purification: Protein G Chromatography
• Gene Name: Homo sapiens integrin binding sialoprotein (IBSP)
• Database Link:
  Entrez Gene 3381 Human
• Background: The protein encoded by the Bone Sialoprotein gene is a major structural protein of the bone matrix. It is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts, and it constitutes approximately 12% of the noncollagenous proteins in human bone. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
• Synonyms: Bone sialoprotein II, BSP II, IBSP, BNSP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: ECM-receptor interaction, Focal adhesion