IL23 (IL23A) Mouse Monoclonal Antibody [Clone ID: HLT2736]
Other products for "IL23A"
Specifications
Product Data | |
Clone Name | HLT2736 |
Applications | IHC, WB |
Recommended Dilution | Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant Human IL23A / IL23 protein |
Specificity | Detects Human recombinant p40 and p19 with elastin linker. |
Formulation | PBS, pH 7.2, sourced in TCS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide |
Concentration | 0.5 mg/ml |
Purification | Affinity Chromatography |
Gene Name | Homo sapiens interleukin 23 subunit alpha (IL23A) |
Database Link | |
Background | The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. |
Synonyms | IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19 |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Documents
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