Integrin alpha 5 (ITGA5) Mouse Monoclonal Antibody [Clone ID: 10F6]

CAT#: AM20393SU-N

Integrin alpha 5 (ITGA5) mouse monoclonal antibody, clone 10F6, Ascites

Product Images

Western blot analysis using ITGA5 antibody against ITGA5-hIgGFc transfected HEK293 cell lysate.

• 

  Human Heart, capillaries: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Flow Cytometric analysis of Hela cells using anti-ITGA5 antibody (green) and negative control (purple).

Specifications

Product Data

• Clone Name: 10F6
• Applications: ELISA, FC, IHC, WB
• Recommended Dilution: ELISA.
  Flow Cytometry: 1/200 - 1/400.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant ITGA5 protein
• Specificity: Recognizes Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide/ITGA5).
• Formulation: State: Ascites
  State: Ascites fluid containing 0.03% Sodium Azide as preservative.
• Gene Name: Homo sapiens integrin subunit alpha 5 (ITGA5)
• Database Link:
  Entrez Gene 3678 Human
• Background: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI).
  In addition to adhesion, integrins are known to participate in cell surface mediated signalling.
• Synonyms: Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, VLA5, FNRA

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton