Cytokeratin 5 (KRT5) Mouse Monoclonal Antibody [Clone ID: 1E1]

CAT#: AM20412SU-N

Cytokeratin 5 (KRT5) mouse monoclonal antibody, clone 1E1, Ascites

Product Images

Western blot analysis using anti-Cytokeratin monoclonal antibody against Hela cell lysate (Lane 1).

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  Prostate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Skin, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Tonsil, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 1E1
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/400.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant fragment of Human KRT5.
• Specificity: Recognizes Cytokeratin 5 (KRT5)
• Formulation: State: Ascites
  State: Ascites fluid containing 0.03% Sodium Azide as preservative.
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens keratin 5 (KRT5)
• Database Link:
  Entrez Gene 3852 Human
• Background: Cytokeratin 5, also known as CK5, KRT5. It is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB). Defects in KRT5 are a cause of epidermolysis bullosa simplex.
  KRT5 encodes the type II keratin 5, an intermediate filament chain expressed largely in stratified squamous epithelia. Mutations in KRT5 cause epidermolysis bullosa simplex.
• Synonyms: KRT5, Cytokeratin-5, Keratin-5, Keratin 5, CK5, K5