ATR (2545-2645) Mouse Monoclonal Antibody [Clone ID: 1E9]

CAT#: AM20413PU-N

ATR (2545-2645) mouse monoclonal antibody, clone 1E9, Purified

Product Images

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 1E9
• Applications: ELISA, IHC
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: aTR (NP_001175, 2545 a.a. ~ 2645 a.a) partial recombinant protein with GST tag
• Specificity: Recognizes Ataxia Telangiectasia and Rad3 Related (ATR) at aa 2545-2645.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Protein A Chromatography
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens ATR serine/threonine kinase (ATR)
• Database Link:
  Entrez Gene 545 Human
• Background: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
• Synonyms: FRAP-related protein 1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cell cycle, p53 signaling pathway