CCR5 Mouse Monoclonal Antibody [Clone ID: T21/8]

CAT#: AM20421PU-N

CCR5 mouse monoclonal antibody, clone T21/8, Aff - Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Clone Name T21/8
Applications ELISA, FC, IHC, IP, WB
Recommended Dilution ELISA.
Flow Cytometry:  This T21/8 (T21/8) antibody has been tested by Flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µl. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Immunohistochemistry on Paraffin Sections: 20 µg/ml.
Immunoprecipitation.
Western Blot.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human CCR5
Specificity Recognizes C-C Chemokine Receptor 5 (CCR5).
Formulation Aqeous buffer containing 0.09% Sodium Azide as preservative and may contain carrier protein/stabilizer
State: Aff - Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Affinity Chromatography
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens C-C motif chemokine receptor 5 (gene/pseudogene) (CCR5), transcript variant A
Background Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a number of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T lymphocytes and by monocytes.
CD195 is rapidly phosphorylated within the C-terminal domain upon ligand stimulation. Recent studies suggest that phosphorylation at Ser337 is mediated by Protein kinase C, whereas phosphorylation at Ser349 is mediated by GPCR kinases.
Synonyms C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CMKBR5, CHEMR13
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.