HDAC3 (224-428) Mouse Monoclonal Antibody [Clone ID: 3A7B5]

CAT#: AM20439SU-N

HDAC3 (224-428) mouse monoclonal antibody, clone 3A7B5, Ascites

Product Images

Western blot analysis using anti-HDAC3 monoclonal antibody against truncated Trx-HDAC3 recombinant protein (Lane 1), full length HDAC3-hIgGFc (aa1-428) transfected CHO-K1 cell lysate (Lane 2) and Hela cell lysate (Lane 3).

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  Brain, cerebellum, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Skin, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 3A7B5
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of HDAC3 (aa224-428) expressed in E. Coli.
• Specificity: Recognizes Histone Deacetylase 3 (HDAC3).
• Formulation: State: Ascites
  State: Ascites fluid containing 0.03% Sodium Azide as preservative
• Gene Name: Homo sapiens histone deacetylase 3 (HDAC3)
• Database Link:
  Entrez Gene 8841 Human
• Background: Histone Ddeacetylase 3, also known as HDAC3, HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
• Synonyms: Histone deacetylase 3, RPD3-2, SMAP45, HD3

Reference Data

• Protein Families: Druggable Genome, Transcription Factors