TNF alpha (TNF) Mouse Monoclonal Antibody [Clone ID: Mab1]

CAT#: AM20447PU-N

TNF alpha (TNF) mouse monoclonal antibody, clone Mab1, Purified


USD 220.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name Mab1
Applications ELISA, FN, WB
Recommended Dilution
Western blot.
ELISA: Can be used as capture antibody in combination with biotinylated antibody MAb11.
Functional application: Neutralization.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human TNF-alpha
Specificity This antibody recognizes human 17-26 kDa cytokine TNF-alpha (tumor necrosis factor alpha).
Formulation PBS, pH 7.4
State: Purified
State: Liquid Ig fraction
Preservative: 0.09% Sodium azide
Concentration lot specific
Purification Protein-A affinity chromatography; > 95% pure by SDS-PAGE
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens tumor necrosis factor (TNF)
Background TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.
Synonyms TNF, TNF-a, TNFA, TNFSF2, Cachectin
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
Protein Pathways Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.