ErbB 3 (ERBB3) Mouse Monoclonal Antibody [Clone ID: 3F10F6]

CAT#: AM20448SU-N

ErbB 3 (ERBB3) mouse monoclonal antibody, clone 3F10F6, Ascites

Product Images

Western blot analysis using monoclonal anti-ERBB3 antibody against truncated Trx-ERBB3 recombinant protein (Lane 1) and MBP-ERBB3 (aa1175-1275) recombinant protein (Lane 2).

• 

  Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 3F10F6
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/400.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant protein encoding amino acids 1175-1275 of Human ERBB3
• Specificity: Recognizes Receptor Protein Tyrosine Kinase ERBB-3 (Her3/ERBB3).
• Formulation: State: Ascites
  State: Ascites fluid containing 0.03% Sodium Azide as preservative
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant s
• Database Link:
  Entrez Gene 2065 Human
• Background: ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.
• Synonyms: ERBB-3, c-erbB-3, HER-3

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, Protein Kinase, Secreted Protein, Stem cell - Pluripotency, Transmembrane
• Protein Pathways: Calcium signaling pathway, Endocytosis, ErbB signaling pathway