Integrin beta 4 (ITGB4) Rat Monoclonal Antibody [Clone ID: 439-9B]

CAT#: AM20454PU-N

Integrin beta 4 (ITGB4) rat monoclonal antibody, clone 439-9B, Purified

Product Images

Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Staining of the A549 cell line with 0.5 ug of Purified Rat IgG2b Isotype Control (open histogram) or 0.5 ug of Purified anti-Human CD104 antibody (439-9B) (colored histogram) followed by Biotin Anti-Rat IgG and Sav-PE. Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: 439-9B
• Applications: FC, IHC, WB
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 20 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Rat
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Human ITGB4
• Specificity: Recognizes Integrin Beta 4 (ITGB4).
• Formulation: Aqueous buffer, 0.09% Sodium Azide, may contain carrier protein/stabilizer
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: 0.5 mg/ml
• Purification: Affinity Chromatography
• Gene Name: Homo sapiens integrin subunit beta 4 (ITGB4), transcript variant 1
• Database Link:
  Entrez Gene 3691 Human
• Background: Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16 alpha and 8 beta subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
• Synonyms: ITGB4, GP150

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton