C5R1 (C5AR1) Mouse Monoclonal Antibody [Clone ID: 3H1738]

CAT#: AM20489PU-N

C5R1 (C5AR1) mouse monoclonal antibody, clone 3H1738, Purified

Product Images

AM20489PU-N C5AR1 Antibody staining of Formalin-Fixed, Paraffin-Embedded Human Placenta at 10 ug/ml after heat-induced antigen retrieval.

Specifications

Product Data

• Clone Name: 3H1738
• Applications: FC, FN, IHC, NEUT
• Recommended Dilution: Flow Cytometry: 1/50.
  Func.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Neut.
• Reactivities: Human, Rabbit
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: C5AR - peptide: Met1 - Asn31.
• Specificity: Recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone 3H1738 was raised against a synthetic peptide Met1 -Asn31 and has recently been shown to recognize the heptameric peptide (D15DKDTLD21).
  Clone 3H1738 inhibits C5a binding to its receptor.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement C5a receptor 1 (C5AR1)
• Database Link:
  Entrez Gene 728 Human
• Background: C5a Anaphylatoxin Receptor mediates the effects of one of the most potent chemotactic agents known, in a wide variety of inflammatory cell types. C5a receptor 1 has been implicated in asthma.
• Synonyms: C5a-R, C5aR, C5AR1, Complement Component 5a Receptor 1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Complement and coagulation cascades, Neuroactive ligand-receptor interaction