PSMA (FOLH1) Mouse Monoclonal Antibody [Clone ID: Y-PSMA2]

CAT#: AM20502PU-N

PSMA (FOLH1) mouse monoclonal antibody, clone Y-PSMA2, Purified

Product Images

Formalin-Fixed, Paraffin-Embedded Human Prostate stained with FOLH1 antibody at 10 ug/ml after heat-induced antigen retrieval.

Specifications

Product Data

• Clone Name: Y-PSMA2
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunofluorescence.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: FOLH1 antibody was raised against crude membrane protein preparation from pooled prostate malignant carcinoma from China.
• Specificity: This antibody recognizes Human PSMA expressed LNCap cell lines.
  Little or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.
• Formulation: PBS, pH 7.0
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein G Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens folate hydrolase 1 (FOLH1), transcript variant 2
• Database Link:
  Entrez Gene 2346 Human
• Background: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.
• Synonyms: Glutamate carboxypeptidase 2, Folate hydrolase 1, Prostate-specific membrane antigen, FOLH, NAALAD1, PSM, GCP2, NAALAdase

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane