Thyroglobulin (TG) Mouse Monoclonal Antibody [Clone ID: n.a]

CAT#: AM20509PU-N

Thyroglobulin (TG) mouse monoclonal antibody, clone n.a, Purified

Product Images

Human Thyroid (formalin-fixed, paraffin-embedded) stained with TG antibody AM20509PU-N at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Clone Name: n.a
• Applications: ELISA, IHC
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: TG antibody was raised against human Thyroglobulin.
• Specificity: This antibody reacts to Thyroglobulin (TG).
• Formulation: PBS, pH 7.4 containing 0.05% sodium azide, before the addition of glycerol to 40%
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Protein G chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens thyroglobulin (TG)
• Database Link:
  Entrez Gene 7038 Human
• Background: Thyroglobulin (TG) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
• Synonyms: Thyreoglobulin, TGN

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Autoimmune thyroid disease