FGFR4 Mouse Monoclonal Antibody [Clone ID: 4H2B10B2]

CAT#: AM20516PU-N

FGFR4 mouse monoclonal antibody, clone 4H2B10B2, Ascites

Product Images

Western blot analysis using FGFR4 monoclonal antibody Cat.-No. AM20516PU-N against truncated FGFR4-Trx-His recombinant protein.

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  Formalin-Fixed, Paraffin-Embedded Human Liver stained with FGFR4 antibody Cat.-No. AM20516PU-N followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Clone Name: 4H2B10B2
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Ni-NTA purified truncated recombinant FGFR4-Trx-His expressed in E. Coli strain BL21 (DE3)
• Specificity: Recognizes CD334 / FGFR4.
• Formulation: State: Ascites
  State: Liquid Ascites with 0.03% Sodium Azide
• Concentration: lot specific
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 1
• Database Link:
  Entrez Gene 2264 Human
• Background: FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
• Synonyms: FGFR-4, JTK2, TKF

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Endocytosis, MAPK signaling pathway, Regulation of actin cytoskeleton