MLH1 Mouse Monoclonal Antibody [Clone ID: n.a]

CAT#: AM20522SU-N

MLH1 mouse monoclonal antibody, clone n.a, Ascites

Product Images

Human Small Intestine (formalin-fixed, paraffin-embedded) stained with MLH1 antibody AM20522SU-N followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Clone Name: n.a
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Immunofluorescence: 1/200 - 1/1000.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: MLH1 antibody was raised against recombinant purified MLH1 protein, aa 381-483.
• Specificity: This antibody reacts to MutL Homolog 1 (colon Cancer, Nonpolyposis Type 2) (MLH1).
• Formulation: Ascites fluid containing 0.03% sodium azide
  State: Ascites
  State: Liquid purified Ascites
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens mutL homolog 1 (MLH1), transcript variant 1
• Database Link:
  Entrez Gene 4292 Human
• Background: MLH1 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.
• Synonyms: DNA mismatch repair protein Mlh1, COCA2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer