gamma Catenin (JUP) Mouse Monoclonal Antibody [Clone ID: CN-3]

CAT#: AM20592PU-N

gamma Catenin (JUP) mouse monoclonal antibody, clone CN-3, Aff - Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name CN-3
Applications IF, IHC, WB
Recommended Dilution Western blot: Use at 0.1 - 0.5 μg/ml with the appropriate system to detect catenin Gamma (plakoglobin) in cells and tissues.
Immunohistochemistry on Frozen Sections: Use at 0.5 - 1.0 μg/ml to detect Catenin Gamma (Plakoglobin) in Formalin/Acetone fixed tissues.
Immunocytochemistry: Use at 1.0 μg/ml
Reactivities Chicken, Human, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant Chicken plakoglobin.
Specificity Recognizes Catenin Gamma (Plakoglobin).
No cross reactivity with other proteins.
Formulation 1.2% Sodium Acetate containing 2mg BSA and 0.01 mg Sodium Azide as preservative.
State: Aff - Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore with 1.2% Sodium Acetate or neutral PBS.
Concentration lot specific
Purification Affinity Chromatography
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens junction plakoglobin (JUP), transcript variant 1
Background Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
Synonyms Desmoplakin-3, Desmoplakin III, Catenin gamma, JUP, CTNNG, DP3
Reference Data
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.