Cathepsin L (CTSL) Mouse Monoclonal Antibody [Clone ID: CP-L14]

CAT#: AM20598PU-N

Cathepsin L (CTSL) mouse monoclonal antibody, clone CP-L14, Aff - Purified

Specifications

Product Data

• Clone Name: CP-L14
• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot: 2 μg/ml.
  Immunohistochemistry on frozen sections: 4 μg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Procathepsin L isolated from the human lung cancer cell line EPLC 32M1.
• Specificity: This antibody reacts to Cathepsin L1.
• Formulation: 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
  State: Aff - Purified
  State: Lyphilized purified Ig fraction
• Reconstitution Method: Restore with 1.2% sodium acetate or neutral PBS.
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Prior to reconstitution store at -20°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens cathepsin L (CTSL), transcript variant 1
• Database Link:
  Entrez Gene 13039 MouseEntrez Gene 25697 RatEntrez Gene 1514 Human
• Background: Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins.Cathepsin L has been implicated in pathologic processes including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists of a heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
• Synonyms: CTSL1, CTSL, MEP, Cathepsin-L1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Antigen processing and presentation, Lysosome