CDK7 Mouse Monoclonal Antibody [Clone ID: IMD-26]
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Specifications
Product Data | |
Clone Name | IMD-26 |
Applications | IF, IHC, WB |
Recommended Dilution | Western Blot: 0.25 μg/ml. Immunohistochemistry on frozen sections: 0.5 μg/ml. Immunocytochemistry. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Recombinant human Cdk7 protein. |
Specificity | This antibody reacts to CDK7. |
Formulation | 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Purified State: Lyphilized purified Ig fraction |
Reconstitution Method | Restore with 1.2% sodium acetate or neutral PBS. |
Concentration | lot specific |
Purification | Affinity chromatography |
Storage | Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens cyclin-dependent kinase 7 (CDK7) |
Database Link | |
Background | CDK-activating kinases (CAKs) are multisubunit proteins that phosphorylate and thus activate certain cyclin-dependent protein kinases in the regulation of cell cycle progression. Cyclin dependent kinase7( CDK7) gene is mapped to chromosome 2p15-cen. CDK7 functions in both cyclin binding and T-loop phosphorylation and that these 2 steps of CDK1 activation are mutually dependent. |
Synonyms | CAK1, P39 Mo15, STK1, CDK-activating kinase |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase, Stem cell - Pluripotency, Transcription Factors |
Protein Pathways | Cell cycle, Nucleotide excision repair |
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