Desmin (DES) Mouse Monoclonal Antibody [Clone ID: DES-82]

CAT#: AM20619PU-N

Desmin (DES) mouse monoclonal antibody, clone DES-82, Purified

Product Images

Immunohistochemistry on Rat cardiac muscle

Specifications

Product Data

• Clone Name: DES-82
• Applications: IHC, WB
• Recommended Dilution: Western Blot: 2 μg/ml.
  Immunohistochemistry on paraffin sections: 2 - 4 μg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Desmin from pig stomach
• Specificity: This antibody reacts to Desmin.
• Formulation: 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
  State: Purified
  State: Lyphilized purified Ig fraction
• Reconstitution Method: Restore with 1.2% sodium acetate or neutral PBS
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Prior to reconstitution store at -20°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens desmin (DES)
• Database Link:
  Entrez Gene 13346 MouseEntrez Gene 64362 RatEntrez Gene 1674 Human
• Background: Desmin belongs to the type III family of intermediate filaments, a class of cytoskeletal elements. DES gene encodes desmin, a muscle-specific cytoskeletal protein found in smooth, cardiac, and heart muscles. Tidball (1992) found that desmin was codistributed with actin thin filaments within the cellular processes of myotendinous junctions in frog skeletal muscle. DES gene contains 9 exons and spans about 8.4 kb. By in situ hybridization, Viegas-Pequignot et al. (1989) localized the gene to 2q35.Desmin mutation responsible for idiopathic dilated cardiomyopathy.
• Synonyms: DES

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)