Dystrophin (DMD) Mouse Monoclonal Antibody [Clone ID: DYS-48]

CAT#: AM20620PU-N

Dystrophin (DMD) mouse monoclonal antibody, clone DYS-48, Purified

Specifications

Product Data

• Clone Name: DYS-48
• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1-2 μg/ml.
  Immunohistochemistry on Paraffin Sections: 2-4 μg/ml (by Heat).
• Reactivities: Human, Mouse, Rabbit, Rat
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant human dystrophin fragment.
• Specificity: This antibody reacts to Dystrophin.
• Formulation: 1.2% Sodium Acetate, with 2 mg BSA and 0.01 mg Sodium Azide as preservative.
  State: Purified
  State: Lyphilized purified Ig fraction
• Reconstitution Method: Restore with 1.2% sodium acetate or neutral PBS
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Prior to reconstitution store at -20°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens dystrophin (DMD), transcript variant Dp427c
• Database Link:
  Entrez Gene 13405 MouseEntrez Gene 24907 RatEntrez Gene 1756 Human
• Background: Dystrophin(DMD) gene has 79 exons spanning at least 2,300 kb (2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain.over expression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.
• Synonyms: BMD; CMD3B; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; dystrophin

Reference Data

• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Viral myocarditis