Insulin (INS) Mouse Monoclonal Antibody [Clone ID: ISL-8J]

CAT#: AM20632PU-N

Insulin (INS) mouse monoclonal antibody, clone ISL-8J, Purified

Product Images

Immunohistochemistry on Rat pancreas sections

Specifications

Product Data

• Clone Name: ISL-8J
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: Use at 0.4-1 μg/ml to detect Insulin in formalin fixed and paraffin embedded tissues.
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody recognizes Insulin.
• Formulation: 1.2% Sodium Acetate, with 2mg BSA and 0.01mg Sodium Azide
  State: Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with 1.2% Sodium Acetate or neutral PBS
• Concentration: lot specific
• Purification: by goat anti-mouse IgG affinity Chromatography
• Storage: Store the antibody after reconstitution at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens insulin (INS), transcript variant 1
• Database Link:
  Entrez Gene 3630 Human
• Background: Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns; exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al. (1981) and Harper and Saunders (1981) assigned the insulin gene to 11p15.5 by in situ hybridization.
• Synonyms: INS

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
• Protein Pathways: Insulin signaling pathway, Maturity onset diabetes of the young, mTOR signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Regulation of autophagy, Type I diabetes mellitus, Type II diabetes mellitus