smooth muscle Myosin heavy chain 11 (MYH11) (smooth) Mouse Monoclonal Antibody [Clone ID: MS-13]

CAT#: AM20644PU-N

smooth muscle Myosin heavy chain 11 (MYH11) (smooth) mouse monoclonal antibody, clone MS-13, Purified

Specifications

Product Data

• Clone Name: MS-13
• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot: 0.25 - 0.5 μg/ml.
  Immunohistochemistry on frozen and paraffin sections: 0.5 - 1 μg/ml.
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human uterus smooth muscle extract
• Specificity: This antibody reacts to Myosin-11 (smooth).
• Formulation: 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
  State: Purified
  State: Lyphilized purified Ig fraction
• Reconstitution Method: Restore with 1.2% sodium acetate or neutral PBS
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Prior to reconstitution store at -20°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens myosin heavy chain 11 (MYH11), transcript variant SM1A
• Database Link:
  Entrez Gene 24582 RatEntrez Gene 4629 Human
• Background: Myosin is composed of 2 heavy chains of about 200,000 daltons each and 4 light chains of about 20,000 daltons each. The light chains are of 2 distinct types: the phosphorylatable, regulatory, or MLC2 type, and the nonphosphorylatable, alkali, or MLC1 and MLC3 types (MYL1 according to the HGM symbols). Skeletal Myosin (Fast), also known as MYL1, mapped to the region 2q32.1-qter. Southern blots of a panel of hybrids containing different portions of human chromosome 16 localized the gene to 16p13.13-p13.12. Skeletal Myosin (slow), also known as light chain 3(MYL3), mapped to 3p. Fodor et al. (1989) found that the MYL3 gene has 7 exons, the last of which is completely untranslated 3-prime sequence.
• Synonyms: SMMHC, MYH11, KIAA0866, Myosin heavy chain 11, smooth muscle

Reference Data

• Protein Pathways: Tight junction, Vascular smooth muscle contraction, Viral myocarditis