N Cadherin (CDH2) Mouse Monoclonal Antibody [Clone ID: NC-17]

CAT#: AM20646PU-N

N Cadherin (CDH2) mouse monoclonal antibody, clone NC-17, Purified

Product Images

Lane 1: Rat liver tissue lysate Lane 2: Rat liver tissue lysate Lane 3: Rat brain tissue lysate Lane 4: Rat testicular tissue lysate Lane 5: Marker (IgG)

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Specifications

Product Data

• Clone Name: NC-17
• Applications: IHC, WB
• Recommended Dilution: Western Blot: 2 μg/ml.
  Immunohistochemistry on frozen sections: 4 μg/ml.
• Reactivities: Chicken, Human, Mouse, Rabbit, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Affinity purified chicken heart A-CAM.
• Specificity: This antibody reacts to Cadherin-2.
• Formulation: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3 (all per vial) as preservative.
  State: Purified
  State: Lyphilized purified Ig fraction
• Reconstitution Method: Restore with 1 ml neutral PBS to achieve stock solutiom of 0.1 mg/ml
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Prior to reconstitution store at -20°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens cadherin 2 (CDH2), transcript variant 1
• Database Link:
  Entrez Gene 12558 MouseEntrez Gene 83501 RatEntrez Gene 1000 Human
• Background: N-cadherin (NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-,and R-cadherin and liver cell adhesion molecule (L-CAM). N-Cadherin,, also known as Cadherin-2,encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene (including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis.
• Synonyms: CDH2, CDHN, NCAD, Neural cadherin, CDw325, Cadherin N, N-Cadherin

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs)