SMAD4 Mouse Monoclonal Antibody [Clone ID: IMD-89]

CAT#: AM20667PU-N

SMAD4 mouse monoclonal antibody, clone IMD-89, Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name IMD-89
Applications IF, WB
Recommended Dilution Western Blot: 2 - 4 μg/ml.
Immunocytochemistry.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human Smad4 (DPC4).
Specificity This antibody reacts to SMAD4.
Formulation 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative
State: Purified
State: Lyphilized purified Ig fraction
Reconstitution Method Restore with 1.2% sodium acetate or neutral PBS
Concentration lot specific
Purification Affinity chromatography
Storage Prior to reconstitution store at -20°C.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens SMAD family member 4 (SMAD4)
Background SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Synonyms SMAD family member 4, SMAD-4, SMAD 4, MADH4, MAD homolog 4, DPC4
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Adherens junction, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.