SCD1 (SCD) Mouse Monoclonal Antibody [Clone ID: CD.E10]

CAT#: AM20836PU-N

SCD1 (SCD) mouse monoclonal antibody, clone CD.E10, Aff - Purified

Specifications

Product Data

• Clone Name: CD.E10
• Applications: ELISA, IHC, IP, WB
• Recommended Dilution: Western blot.
  ELISA.
  Immunoprecipitation.
  Immunohistochemistry on frozen sections.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Full length recombinant protein
• Specificity: This antibody reacts to SCD / SCD1.
• Formulation: PBS, pH 7.4 with 0.05% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens stearoyl-CoA desaturase (SCD)
• Database Link:
  Entrez Gene 6319 Human
• Background: Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355aa, rat 358aa; ~37 KDa) is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. The SCD-1 expression is higher in female than male mouse. The repression of RNA levels and enzyme activity of hepatic SCD-1 by Leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 could be of benefit for treatment of obesity, hepatic steatosis and other metabolic disorders.
• Synonyms: Acyl-CoA desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Biosynthesis of unsaturated fatty acids, PPAR signaling pathway