JAB1 (COPS5) (full length) Mouse Monoclonal Antibody [Clone ID: 8H8.5]

CAT#: AM20857PU-N

JAB1 (COPS5) (full length) mouse monoclonal antibody, clone 8H8.5, Purified

Product Images

Human Brain: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 8H8.5
• Applications: IHC, IP, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/100.
  Immunoprecipitation.
  Western Blot.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant protein corresponding to the full-length Mouse JAB-1 gene expressed in E. coli.
• Specificity: This antibody recognizes full-length mouse JAB-1.
• Formulation: Phosphate buffer, pH 7.4, Carrier, without preservatives
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Protein G Chromatography
• Gene Name: Homo sapiens COP9 signalosome subunit 5 (COPS5)
• Database Link:
  Entrez Gene 26754 MouseEntrez Gene 10987 Human
• Background: JAB-1 is a 38a protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
• Synonyms: Signalosome subunit 5, SGN5, CSN5, JAB1

Reference Data

• Protein Families: Druggable Genome, Protease, Transcription Factors