Fasl Hamster Monoclonal Antibody [Clone ID: MFL4]

CAT#: AM20860PU-S

Fasl hamster monoclonal antibody, clone MFL4, Purified

Specifications

Product Data

• Clone Name: MFL4
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl of 1/25-1/200 diluted antibody to label 1x10e6 cells in 100 µl.
• Reactivities: Mouse, Rat
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: B6 Mouse FasL/BHK cells
• Specificity: Recognizes both Mouse and Rat CD178.
  Clone MFL4 is reported to block CD178/CD95 induced apoptosis. We recommend the use of AM20860LE-N for functional studies.
• Formulation: PBS containing 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography on Protein G
• Gene Name: Mus musculus Fas ligand (TNF superfamily, member 6) (Fasl), transcript variant 1
• Database Link:
  Entrez Gene 14103 Mouse
• Background: CD178, otherwise known as Fas Ligand/ CD95L, a 40kDa type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection.
  CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis.
• Synonyms: FASLG, APT1LG1, FASL, TNFSF6, CD95L protein, APTL