SMAD6 (285-385) Mouse Monoclonal Antibody [Clone ID: 2A6]
Other products for "SMAD6"
Specifications
Product Data | |
Clone Name | 2A6 |
Applications | ELISA, IHC, WB |
Recommended Dilution | ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | SMAD6 (NP_005576, 285 a.a. ~ 385 a.a) partial recombinant protein with GST tag. |
Specificity | This antibody reacts to SMAD, Mothers Against DPP Homolog 6 (SMAD6) at aa 285-385. |
Formulation | PBS, pH 7.4 State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein A Chromatography |
Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens SMAD family member 6 (SMAD6), transcript variant 2 |
Database Link | |
Background | Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. |
Synonyms | SMAD family member 6, SMAD 6, SMAD-6, MADH6, MAD homolog 6 |
Reference Data | |
Protein Families | Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors |
Protein Pathways | TGF-beta signaling pathway |
Documents
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.