SMAD6 (285-385) Mouse Monoclonal Antibody [Clone ID: 2A6]

CAT#: AM20913PU-N

SMAD6 (285-385) mouse monoclonal antibody, clone 2A6, Purified

Product Images

Detection limit for recombinant GST tagged SMAD6 is approximately 3 ng/ml as a capture antibody.

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  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 2A6
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: SMAD6 (NP_005576, 285 a.a. ~ 385 a.a) partial recombinant protein with GST tag.
• Specificity: This antibody reacts to SMAD, Mothers Against DPP Homolog 6 (SMAD6) at aa 285-385.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A Chromatography
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens SMAD family member 6 (SMAD6), transcript variant 2
• Database Link:
  Entrez Gene 4091 Human
• Background: Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
• Synonyms: SMAD family member 6, SMAD 6, SMAD-6, MADH6, MAD homolog 6

Reference Data

• Protein Families: Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
• Protein Pathways: TGF-beta signaling pathway