NR1D1 Mouse Monoclonal Antibody [Clone ID: 4F6]

CAT#: AM20975PU-N

NR1D1 mouse monoclonal antibody, clone 4F6

Product Images

NR1D1 monoclonal antibody clone 4F6 Western Blot analysis of NR1D1 expression in Hela NE.

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  NR1D1 monoclonal antibody, clone 4F6. Western Blot analysis of NR1D1 expression in NIH/3T3.

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  Detection limit for recombinant GST tagged NR1D1 is approximately 1 ng/ml as a capture antibody.

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  Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence of monoclonal antibody to NR1D1 on HeLa cell (antibody concentration 10 ug/ml).

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Specifications

Product Data

• Clone Name: 4F6
• Applications: ELISA, IF, IHC, RNAi, WB
• Recommended Dilution: ELISA.
  Immunofluorescence: 10 µg/ml.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  RNAi.
  Western Blot.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant protein, NR1D1 (AAH56148, 1 a.a. ~ 615 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Specificity: This antibody recognizes Nuclear Receptor Rev-ErbA Alpha (NR1D1).
• Formulation: PBS, pH 7.2
  State: Liquid purfied Ig fraction
• Concentration: 0.48 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1)
• Database Link:
  Entrez Gene 217166 MouseEntrez Gene 9572 Human
• Background: Rev-erbA alpha, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). Rev-erbA alpha is a target of Nuclear Receptor ROR Alpha (Delerive et al. 2002), and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Recently Reb-erbA alpha has been shown to affect circadian rhythms by regulating cyclic Bmal1 transcription ( Preitner et al. 2002, Ueda et al. 2002). Mice lacking Rev-erbA alpha show abnormal postnatal cerebellar development.
• Synonyms: EAR1, HREV, THRAL

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Circadian rhythm - mammal