TDP43 (TARDBP) (1-261) Mouse Monoclonal Antibody [Clone ID: 2E2-D3]

CAT#: AM20994PU-N

TDP43 (TARDBP) (1-261) mouse monoclonal antibody, clone 2E2-D3, Purified

Product Images

Western Blot analysis of TARDBP expression in transfected 293T cell line by TARDBP monoclonal antibody clone 2E2-D3.

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  TARDBP monoclonal antibody clone 2E2-D3 Western Blot analysis of TARDBP expression in A-431.

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  Western blot analysis of TARDBP over-expressed 293 cell line, cotransfected with TARDBP Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with TARDBP monoclonal antibody clone 2E2-D3.

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  Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

• Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell (antibody concentration 10 ug/ml).

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Specifications

Product Data

• Clone Name: 2E2-D3
• Applications: ELISA, IF, IHC, RNAi, WB
• Recommended Dilution: ELISA.
  Immunofluorescence: 10 µg/ml.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  RNAi.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: TARDBP (AAH01487, 1 a.a. ~ 261 a.a) full length recombinant protein with GST tag
• Specificity: This antibody reacts to TAR DNA-binding Protein-43 (TARDBP) at aa 1-261.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.48 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens TAR DNA binding protein (TARDBP)
• Database Link:
  Entrez Gene 23435 Human
• Background: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division.
• Synonyms: TDP43, TDP-43

Reference Data

• Protein Families: Transcription Factors