Cd80 Hamster Monoclonal Antibody [Clone ID: 16-10A1]

CAT#: AM26002PU-N

Cd80 hamster monoclonal antibody, clone 16-10A1, Aff - Purified

Specifications

Product Data

• Clone Name: 16-10A1
• Applications: FC, FN, IHC, IP
• Recommended Dilution: Flow Cytometry: 6 μg/ml.
  Immunoprecipitation.
  Immunohistochemistry on Frozen Sections.
  Functional Application: Blocking.
• Reactivities: Canine, Mouse
• Host: Hamster
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: CD80-transfected CHO cell line
• Specificity: This Hamster antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
• Formulation: Phosphate buffered saline (PBS), pH~7.4 with 15 mM Sodium Azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Protein-A affinity chromatography
• Gene Name: Mus musculus CD80 antigen (Cd80)
• Database Link:
  Entrez Gene 12519 Mouse
• Background: CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
• Synonyms: CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1