CD19 Mouse Monoclonal Antibody [Clone ID: 4G7]

CAT#: AM26006RP-N

CD19 mouse monoclonal antibody, clone 4G7, PE


USD 300.00

2 Weeks*

Size
    • 100 Tests

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Specifications

Product Data
Clone Name 4G7
Applications FC
Recommended Dilution Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human CCL (chronic lymphocytic leukemia) cells
Specificity This antibody recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
Formulation Phosphate buffered saline (PBS) containing 15 mM sodium azide
Label: PE
State: Liquid purified Ig fraction
Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation PE
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens CD19 molecule (CD19), transcript variant 2
Background CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Synonyms Leu-12, B-cell marker
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway, Hematopoietic cell lineage, Primary immunodeficiency

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.