GRAP2 Mouse Monoclonal Antibody [Clone ID: UW40]

CAT#: AM26008PU-N

GRAP2 mouse monoclonal antibody, clone UW40, Aff - Purified


USD 270.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name UW40
Applications FC, IP, WB
Recommended Dilution Flow cytometry: 1 μg/ml.
Immunoprecipitation.
Western blot.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen GST-fusion human GRAP2/GADS protein
Specificity This antibody detects recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State: Aff - Purified
State: Liquid Ig fraction
Concentration 1.0 mg/ml
Purification Protein-A affinity chromatography
Gene Name Homo sapiens GRB2-related adaptor protein 2 (GRAP2), transcript variant 3
Background GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
Synonyms GADS, GRBLG, GRB2L, Grf-40, GRBX, GRID
Reference Data
Protein Families Druggable Genome
Protein Pathways T cell receptor signaling pathway

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