GRAP2 Mouse Monoclonal Antibody [Clone ID: UW40]

CAT#: AM26008PU-N

GRAP2 mouse monoclonal antibody, clone UW40, Aff - Purified

Specifications

Product Data

• Clone Name: UW40
• Applications: FC, IP, WB
• Recommended Dilution: Flow cytometry: 1 μg/ml.
  Immunoprecipitation.
  Western blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: GST-fusion human GRAP2/GADS protein
• Specificity: This antibody detects recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Protein-A affinity chromatography
• Gene Name: Homo sapiens GRB2-related adaptor protein 2 (GRAP2), transcript variant 3
• Database Link:
  Entrez Gene 9402 Human
• Background: GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
• Synonyms: GADS, GRBLG, GRB2L, Grf-40, GRBX, GRID

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: T cell receptor signaling pathway