CD62P (SELP) Mouse Monoclonal Antibody [Clone ID: AK4]

CAT#: AM26020FC-N

CD62P (SELP) mouse monoclonal antibody, clone AK4, FITC


USD 270.00

2 Weeks*

Size
    • 100 Tests

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Specifications

Product Data
Clone Name AK4
Applications FC
Recommended Dilution Flow Cytometry analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension.
Reactivities Human, Primate
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human platelets
Specificity This antibody recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation.
Formulation Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Label: FITC
State: Liquid purified Ig fraction
Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use
Conjugation FITC
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens selectin P (SELP)
Background CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.
Synonyms SELP, GMRP, GRMP, PADGEM, GMP-140, LECAM3
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.