TAPA1 (CD81) Mouse Monoclonal Antibody [Clone ID: M38]

CAT#: AM26031PU-N

TAPA1 (CD81) mouse monoclonal antibody, clone M38, Purified

Specifications

Product Data

• Clone Name: M38
• Applications: FC, FN, IF, IHC, IP, WB
• Recommended Dilution: Flow cytometry: 1 µg/ml.
  Immunoprecipitation.
  Western blot.
  Immunohistochemistry on paraffin sections.
  Immunocytochemistry.
  Functional Application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines.
• Reactivities: Feline, Human, Rabbit
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: MOLT-4 (human T-ALL cell line)
• Specificity: This antibody reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  State: Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein-A affinity chromatography (> 95% by SDS-PAGE)
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens CD81 molecule (CD81), transcript variant 1
• Database Link:
  Entrez Gene 975 Human
• Background: CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells – e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
• Synonyms: S5.7; TAPA-1; TAPA1; Tetraspanin-28; Tspan-28; TSPAN28

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: B cell receptor signaling pathway