HSP90AB1 Mouse Monoclonal Antibody [Clone ID: MBH90B]

CAT#: AM26035PU-N

HSP90AB1 mouse monoclonal antibody, clone MBH90B, Aff - Purified


USD 300.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name MBH90B
Applications IF, IP, WB
Recommended Dilution Immunoprecipitation: 1 μg/ml.
Western blot: 1 μg/ml.
Immunocytochemistry: 1 μg/ml.
This clone has been desribe to work in Immunohistochemistry on Paraffin Sections.
Reactivities Bovine, Human, Mouse
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Peptide within N-terminal part of human Hsp90
Specificity This antibody recognizes the EEVHHG epitope within the N-terminal part of Hsp90 beta an ubiquitously expressed protein with calculated Mw of 83.3 kDa, however, migrating as a 90 kDa band under reducing SDS-PAGE conditions.
Formulation Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Protein-A affinity chromatography (> 95% by SDS-PAGE)
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens heat shock protein 90kDa alpha family class B member 1 (HSP90AB1), transcript variant 2
Background Hsp90 beta (heat shock protein 90 beta) is a constitutively expressed isoform of Hsp90, one of the most abundant chaperones in the cytosol of eukaryotic cells. Hsp90 interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis.
Synonyms HSP90B, HSPC2, HSPCB, Heat shock protein HSP 90-beta, Heat shock 84 kDa, HSP84
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.