CD20 (MS4A1) Mouse Monoclonal Antibody [Clone ID: CAT13.6E12]

CAT#: AM26056PU-N

CD20 (MS4A1) mouse monoclonal antibody, clone CAT13.6E12, Aff - Purified


USD 435.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name CAT13.6E12
Applications FC, IHC
Recommended Dilution Immunohistochemistry on Frozen Sections: 0.2 μg/ml (1/1000).
Has been described to work in FACS.
Recommended Positive Control: Human tonsil.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody CAT13.6E12 recognizes the CD20 antigen. 
Antigen distribution on Isolated cells: The antibody stains 5-20% of human peripheral blood mononuclear cells in flow cytometry.
Formulation PBS, pH 7.2
State: Aff - Purified
State: Lyophilized purified Ig fraction
Stabilizer: 5mg/ml BSA
Preservative: 0.09% Sodium Azide
Reconstitution Method Restore by adding 0.5 ml distilled water
Concentration 0.2 mg/ml (after reconstitution)
Purification Affinity Chromatography
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens membrane spanning 4-domains A1 (MS4A1), transcript variant 3
Background CD20 belongs to the MS4A family (Membrane-spanning 4-domains subfamily A). Its expression is restricted to normal and neoplastic B cells. It is expressed by pre-B cells in the bone marrow, and expression persists during B cell maturation but is lost upon terminal differentiation into plasma cells.
CD20 is not glycosylated. CD20 is not phosphorylated in resting B cells, but becomes heavily phosphorylated after mitogen stimulation. Three cell surface isoforms 33, 35 and 37kD, result from differential phosphorylation of a single core 33kD protein within the cytoplasmic domain. Multiple proteins are coimmunoprecipitated with CD20, suggesting that it may be a component of a multimeric surface receptor complex. Monoclonal antibodies against CD20 are used therapeutically, such as Rituximab (Mabthera) or Britumomab (Zevalin).
Synonyms MS4A1, Leu-16, Bp35, B-cell marker
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Hematopoietic cell lineage

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.