CD20 (MS4A1) Mouse Monoclonal Antibody [Clone ID: CAT13.6E12]
CAT#: AM26056PU-N
CD20 (MS4A1) mouse monoclonal antibody, clone CAT13.6E12, Aff - Purified
Other products for "MS4A1"
Specifications
Product Data | |
Clone Name | CAT13.6E12 |
Applications | FC, IHC |
Recommended Dilution | Immunohistochemistry on Frozen Sections: 0.2 μg/ml (1/1000). Has been described to work in FACS. Recommended Positive Control: Human tonsil. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Specificity | This antibody CAT13.6E12 recognizes the CD20 antigen. Antigen distribution on Isolated cells: The antibody stains 5-20% of human peripheral blood mononuclear cells in flow cytometry. |
Formulation | PBS, pH 7.2 State: Aff - Purified State: Lyophilized purified Ig fraction Stabilizer: 5mg/ml BSA Preservative: 0.09% Sodium Azide |
Reconstitution Method | Restore by adding 0.5 ml distilled water |
Concentration | 0.2 mg/ml (after reconstitution) |
Purification | Affinity Chromatography |
Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens membrane spanning 4-domains A1 (MS4A1), transcript variant 3 |
Database Link | |
Background | CD20 belongs to the MS4A family (Membrane-spanning 4-domains subfamily A). Its expression is restricted to normal and neoplastic B cells. It is expressed by pre-B cells in the bone marrow, and expression persists during B cell maturation but is lost upon terminal differentiation into plasma cells. CD20 is not glycosylated. CD20 is not phosphorylated in resting B cells, but becomes heavily phosphorylated after mitogen stimulation. Three cell surface isoforms 33, 35 and 37kD, result from differential phosphorylation of a single core 33kD protein within the cytoplasmic domain. Multiple proteins are coimmunoprecipitated with CD20, suggesting that it may be a component of a multimeric surface receptor complex. Monoclonal antibodies against CD20 are used therapeutically, such as Rituximab (Mabthera) or Britumomab (Zevalin). |
Synonyms | MS4A1, Leu-16, Bp35, B-cell marker |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Hematopoietic cell lineage |
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