CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: c127]

CAT#: AM26063PU-N

CD16 (FCGR3A) mouse monoclonal antibody, clone c127, Aff - Purified


USD 435.00

2 Weeks*

Size
    • 200 ug

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Specifications

Product Data
Clone Name c127
Applications FC, IHC, IP
Recommended Dilution Immunohistochemistry on Frozen Sections (Reacts mainly with granulocytes): 0.5 µg/ml (1/800).
Has been described to work in FACS and Immunoprecipitation.
Suggested Positive Control: Human placenta.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity The antibody recognizes CD16, the low affinity receptor for IgG (FcγRIII). It detects both isoforms. The antigen is strongly expressed on granulocytes in most tissues.
Antigen Distribution:
Isolated cells: On flow cytometry it stains approximately 2-15% of peripheral blood lymphocytes.
Tissue Sections: The antigen is strongly expressed on granulocytes in most tissues.
Formulation Stock solution contains 0.4 mg/ml IgG, Phosphate Buffered Saline pH 7.2 (PBS)
State: Aff - Purified
State: Lyophilized purified Ig fraction
Stabilizer: 5 mg/ml BSA
Preservative: 0.09% Sodium Azide
Reconstitution Method Restore by adding 0.5 ml distilled water.
Purification Affinity Chromatography
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens Fc fragment of IgG receptor IIIa (FCGR3A), transcript variant 1
Background CD16 is expressed on the majority of NK cells, on granulocytes, monocytes and macrophages, and on a subset of T cells. CD16 is involved in antibody-dependent cellular cytotoxicity (ADCC). This molecule is encoded by FcγRIII-A or FcγRIII-B genes. The genetic heterogeneity of FcγRIII generates alternative membrane-anchored proteins with distinct signalling capacities when cross-linked by immune complexes.
CD16 exists in two distinct forms, as a single-pass type I integral membrane protein (CD16a), and as a glycosyl phosphatidyl inositol (GPI) form (CD16b). In humans, the transmembrane form is expressed on NK cells and macrophages while the GPI linked form is expressed on granulocytes.
Synonyms FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2
Reference Data
Protein Families ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.