CD163 Mouse Monoclonal Antibody [Clone ID: GHI/61]

CAT#: AM26138RP-N

CD163 mouse monoclonal antibody, clone GHI/61, PE

Product Images

Surface staining of human peripheral blood using anti-human CD163 (clone GHI/61) PE.

Specifications

Product Data

• Clone Name: GHI/61
• Applications: FC
• Recommended Dilution: Flow cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Hairy cell leukemia cells
• Specificity: This antibody recognizes CD163, an approximately 130 kDa high affinity scavenger receptor expressed mainly on monocytes and macrophages, which binds hemoglobin-haptoglobin complex.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
  Label: PE
  State: Liquid purified Ig fraction
• Purification: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
• Conjugation: PE
• Gene Name: Homo sapiens CD163 molecule (CD163), transcript variant 1
• Database Link:
  Entrez Gene 9332 Human
• Background: CD163, also known as M130, is a member of the scavenger receptor family, accounting for the clearance of hemoglobin-haptoglobin complexes during limited hemolysis, which protects the body, in particular the kidneys, against heme-mediated oxidative damages. It does not have measurable affinity for noncomplexed hemoglobin or haptoglobin. Immunomodulatory role of CD163 has been postulated. CD163 is expressed by cells of the monocyte-macrophage lineage and its extracellular part also circulates in plasma as a soluble protein, especially during sepsis and other conditions affecting macrophage activity, when its level may raise manyfold.
• Synonyms: M130, Hemoglobin scavenger receptor, Macrophage marker

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane