LY75 (LY75-CD302) Mouse Monoclonal Antibody [Clone ID: HD30]

CAT#: AM26139RP-N

LY75 (LY75-CD302) mouse monoclonal antibody, clone HD30, PE

Product Images

Surface staining of human peripheral blood monocytes with anti-CD205 (HD30) PE.

Specifications

Product Data

• Clone Name: HD30
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension.
  The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Fc-tagged human CD205
• Specificity: This antibody detects CD205.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
  Label: PE
  State: Liquid purified Ig fraction
  Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use
• Conjugation: PE
• Gene Name: Homo sapiens LY75-CD302 readthrough (LY75-CD302), transcript variant 1
• Database Link:
  Entrez Gene 100526664 Human
• Background: CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.
• Synonyms: LY75, CLEC13B, DEC205, gp200-MR6