CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: VIPL2]
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Specifications
Product Data | |
Clone Name | VIPL2 |
Applications | FC, IHC, WB |
Recommended Dilution | Flow Cytometry Western blot. Immunohistochemistry on Frozen Sections. |
Reactivities | Human, Primate |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Specificity | This Mouse monoclonal antibody VIPL2 recognizes CD61, a 90-110 kDa transmembrane glycoprotein of integrin family, expressed on platelets, megacaryocytes, osteoclasts, endothelial cells and other cell types, including leucocytes and smooth muscle cells. HLDA V.; WS Code 5T-124 |
Formulation | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Storage | Store undiluted at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens integrin subunit beta 3 (ITGB3) |
Database Link | |
Background | CD61 (beta3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells. |
Synonyms | Integrin beta-3, GP3A, GPIIIa |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton |
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