Pentraxin 3 (PTX3) Rat Monoclonal Antibody [Clone ID: MNB1]

CAT#: AM26188PU-N

Pentraxin 3 (PTX3) rat monoclonal antibody, clone MNB1, Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name MNB1
Applications ELISA, FN, IHC, IP, WB
Recommended Dilution Immunohistochemistry on Frozen Sections.
Immunohistochemistry on Paraffin Sections.
Western blot.
The typical starting working dilution is 1/50.
Functional Assays.
Immunoassays.
Immunoprecipitation.
Reactivities Human
Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen Human recombinant PTX3
Specificity The monoclonal antibody MNB1 recognizes Human Pentraxin 3 (PTX3), belonging to the long Pentraxin family.
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% BSA
Preservative: 0.02% Sodium Azide
Concentration lot specific
Purification Protein G Chromatography
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Gene Name pentraxin 3
Background PTX3 is an acute-phase glycoprotein of ~45 kDa with glycosylation accounting for about 10% of its molecular weight. PTX3 has a complex oligomeric structure with protomers linked to each other by disulfide bonds. PTX3 expression is triggered by inflammatory cytokines, resulting in higher levels of circulating PTX3. Several cell types have been reported to produce PTX3, namely macrophages, endothelial cells, neutrophils and synoviocytes. PTX3 is involved in host defense against pathogen infection, in the regulation of the scavenger activity of macrophages and dendritic cells, and in modulation of complement activity by binding to C1q. Furthermore, PTX3 has been implicated in matrix deposition of cumulus cells. Moreover, PTX3 interacts with other biologically active molecules, causing their functional blockade. This has been demonstrated for fibroblast growth factor-2 (FGF-2), for which PTX3 acts as an inhibitor, leading to inhibition of angiogenesis. PTX3, like other pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP), binds apoptotic cells and debris. PTX3 is useful as an early indicator of myocyte irreversible injury in ischemic cardiomyopathy. PTX3 is not only involved in inflammatory vessel diseases related to atherosclerosis, but also in pre-eclampsia and systemic small vessel ANCA-associated vasulitis, in which neutrophils are key players. The relationship between tissue damage and pentraxin generation is stringent in acute injuries. PTX3 tunes self-non-self discrimination and tissue repair due to the recognition of diverse ligands by PTX3 and through regulation of effector pathways.
Synonyms TNFAIP5, TSG14, TSG-14, Pentraxin-related protein PTX3, Pentaxin-related protein PTX3
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.