C3AR1 Mouse Monoclonal Antibody [Clone ID: 17]

CAT#: AM26212FC-N

C3AR1 mouse monoclonal antibody, clone 17, FITC

Specifications

Product Data

• Clone Name: 17
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on frozen sections.
  Flow cytometry.
  The typical starting working dilution is 1:50.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Specificity: This antibody reacts with the receptor for C3a. It does not block binding of ligand to C3aR.
• Formulation: PBS
  Label: FITC
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Conjugation: FITC
• Storage:

  Store at 2 - 8 °C.
  

• Stability: Shelf life: one year from despatch.

• Gene Name: complement component 3a receptor 1
• Database Link:
  Entrez Gene 719 Human
• Background: In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in, myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.
• Synonyms: C3a-R, C3AR, C3AR1, AZ3B, C3R1, HNFAG09
• Note: The monoclonal antibody 17 is in the literature also referred to as clone hC3aRZ8.