Protein S (PROS1) Rat Monoclonal Antibody [Clone ID: PS7]

CAT#: AM26230FC-N

Protein S (PROS1) rat monoclonal antibody, clone PS7, FITC


USD 445.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name PS7
Applications WB
Recommended Dilution Flow Cytometry: 1/50.
Western blot: 1/50.
Reactivities Human
Host Rat
Isotype IgG2a
Clonality Monoclonal
Specificity Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa.
Allows specific detection of cells carrying PS by flow cytometry.
Formulation PBS
Label: FITC
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 1% BSA
Preservative: 0.02% Sodium Azide
Concentration lot specific
Purification Protein G Chromatography
Conjugation FITC
Storage

Store undiluted at 2-8°C.

Stability Shelf life: one year from despatch.

Gene Name protein S (alpha)
Background In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain.
Synonyms PROS
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.