Protein S (PROS1) Rat Monoclonal Antibody [Clone ID: PS7]

CAT#: AM26230PU-N

Protein S (PROS1) rat monoclonal antibody, clone PS7, Purified

Specifications

Product Data

• Clone Name: PS7
• Applications: WB
• Recommended Dilution: Flow Cytometry: 1/50.
  Western blot: 1/50.
• Reactivities: Human
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa.
  Allows specific detection of cells carrying PS by flow cytometry.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Cchromatography on Protein G
• Storage:

  Store undiluted at 2-8°C.

• Stability: Shelf life: one year from despatch.

• Gene Name: protein S (alpha)
• Database Link:
  Entrez Gene 5627 Human
• Background: In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain.
• Synonyms: PROS